Thursday, October 6, 2011

The Organic Chemistry of Drug Design and Drug Action, Second Edition

The Organic Chemistry of Drug Design and Drug Action, Second Edition

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Product Description

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction.


* Presents an organic chemist's perspective of how drugs are designed and function
* Includes extensive references and illustrations, plus new problems and exercises to help students learn
* Written in a casual style that provides unmatched clarity and understanding
* Author has published 200+ articles, earned 21 patents, and invented a drug that is under consideration for commercialization

The Organic Chemistry of Drug Design and Drug Action, Second Edition Review

This is probably the best book of its kind in the vast and multidisciplinary field of drug design and action. Richard Silverman is an acclaimed chemistry professor at Northwestern University, and in this book he provides the most comprehensive and lucid exposition of the chemical basis of drug action that I have seen. No matter how complicated biological systems and their interactions are, at the basic level it's all chemistry, and mostly organic chemistry. Thus, understand the chemistry and you will go a long way in understanding drug action. An organic chemist will find this book extremely illuminating in a way that would not have been made clear through his traditional education.

The book opens with a short but clear discussion of drug discovery, combinatorial chemistry, patents and clinical trials. Then it leads the reader through a variety of enzyme catalyzed reactions, with examples of major drugs studded all the way. Silverman shows us how nature is the master organic chemist, employing the familiar reactions of chemistry in an unsurpassed manner. The chapter on enzyme inhibition is long and detailed and it's breathtaking. This is a key chapter because almost all major drugs act by inhibiting enzymes. The examples which Silverman chooses to illustrate are both important (including many bestselling anticancer, antiviral, and antibiotic drugs to name a few), as well as very interesting. The last parts of the book deal with DNA binding drugs and with pathways of drug metabolism and excretion. Along all the way, the emphasis is on the chemical reactions that drugs undergo, which are after all the key to understanding their properties. The lucidity of the book is such that a beginning graduate or advanced undergraduate well-versed with the basic principles of general and organic chemistry can easily understand all the contents.

I would say that this book is so interesting and illuminating that it's one of the very few academic books which you can enjoyably read cover to cover. In fact it even makes great bedside reading! Truly a must-have book for chemists and biologists of every kind interested in how drugs work.

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Wednesday, October 5, 2011

Plant Nutrition and Soil Fertility Manual, Second Edition

Plant Nutrition and Soil Fertility Manual, Second Edition

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Product Description

As soil and crop management procedures have become more complex, County Agricultural Agents, farm advisors, consultants, and fertilizer and chemical dealers have had to specialize in some aspect of soil fertility and crop nutrition management procedures, limiting their ability to provide a range of advice and services. Most farmers and growers can no longer turn to just one source for the information and instruction needed to achieve their production goals.



With over 70 percent new material, the second edition of the Plant Nutrition and Soil Fertility Manual discusses the principles determining how plants grow and the elements essential for successful crop production, with a focus on the principles of soil fertility and plant nutrition. The book covers physical and chemical properties of soil, chemical and organic fertilizers, soil acidity and alkalinity, liming and liming materials, and micronutrients essential to plant growth. It also describes elements toxic to plants, soil testing, and plant analysis.



The topics and discussion in this self-contained book are practical and user-friendly, yet comprehensive enough to cover material presented in upper-level soil and plant science courses. It allows practitioners with general background knowledge to feel confident applying the principles presented to soil/crop production systems.

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Plant Nutrition and Soil Fertility Manual, Second Edition Review

This is a nice compact book that can be used to teach plant nutrition. The directions on making DIY kits for tissue analysis are interesting. I wish the author had icluded a guiding range of values corresponding to the five elemental requirement categories in Appendix D.

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Tuesday, October 4, 2011

Withrow and MacEwen's Small Animal Clinical Oncology

Withrow and MacEwen's Small Animal Clinical Oncology

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Product Description

Focusing on cancer in dogs and cats, this extensively updated 4th edition provides comprehensive coverage of the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. Ideal for students, practitioners, and those involved in academic research, this book's full-color images and user-friendly format provide quick and easy access to today's most important information on cancer in the small animal patient.
  • Full-color format throughout and full-color illustrations make information more accessible and provide accurate representations of clinical appearance.
  • Chapters are clustered into four major sections: The Biology and Pathogenesis of Cancer, Diagnostic Procedures for the Cancer Patient, Therapeutic Modalities for the Cancer Patient, and Specific Malignancies in the Small Animal Patient.
  • The consistent format includes incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies in the small animal cancer patient.
  • Features cutting edge information on the complications of cancer, pain management, and the latest treatment modalities.
  • The latest information on the etiology of cancer, including genetic, chemical, physical, and hormonal factors, as well as cancer-causing viruses.
  • Coverage of molecular-targeted therapy of cancer, plus new and emerging therapeutic techniques.
  • New information on molecular diagnostic procedures for the cancer patient.
  • The latest diagnostic imaging techniques in clinical oncology.
  • Discussions of compassion and supportive care, from chronic pain management and nutrition to end-of-life issues and grief support.

Withrow and MacEwen's Small Animal Clinical Oncology Review

I am currently finishing up an advanced clinical rotation in surgical and medical oncology at the Michigan State University College of Veterinary Medicine. I bought this book as a main resource, along with Fossum's surgery text, Slatter's, and Nelson/Couto's medical text. Withrow's book has been extremely helpful with the background information required to diagnose, treat, and predict the behavior of most tumors. I would recommend this book to anyone specializing in oncology, surgery, internal medicine, or even the general practicioner.

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Monday, October 3, 2011

Fundamentals of Turfgrass Management

Fundamentals of Turfgrass Management

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Product Description

Now revised & updated -- the essential book on turfgrass management!

The new edition of Fundamentals of Turfgrass Management introduces the principles of turfgrass management, covering everything from basic turfgrass science to fertilization, mowing, turfgrass diseases, irrigation topdressing, pest management, as well as career paths, and much more.

With an emphasis on explaining why certain management practices are handled as they are, this new edition:

  • Incorporates updates throughout with special emphasis on pesticides, herbicides, insecticides, fungicides, and soil testing
  • Contains expanded coverage of physiology, water quality and seed production, seed certification, and seed buying
  • Offers step-by-step advice on the selection and maintenance of turfgrasses
  • Includes the latest information on cutting-edge fertilization research, mowing techniques, and sports field management practices
  • Features a full-color identification guide that covers the most common grasses and weeds

Written on a level suitable for students, but with a wealth of information useful to experienced turfgrass managers, Fundamentals of Turfgrass Management, Fourth Edition provides a solid yet flexible grounding that readers can apply and adapt on the job to nearly any situation.

Fundamentals of Turfgrass Management Review

This introductory-level book provides the beginner with the basics of turfgrass management. Scientific names are as up-to-date as possible for the turfgrasses as well as pests that invade them. Diagrams / photos of grasses and grass pests could be more extensive, but the cost of the book would likely escalate beyond the nominal price of this volume, which makes it attractive for use as a text in an entry-level turfgrass course.

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Sunday, October 2, 2011

Breast Cancer (MD Anderson Cancer Care Series)

Breast Cancer (MD Anderson Cancer Care Series)

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Product Description

Now in this, its second edition, this fully revised clinical guidebook is an essential resource for the practitioner, allowing quick, authoritative access to the latest and best in multimodality therapies. Topics covered in this volume include everything from screening for early detection of breast cancer, through diagnostic radiology and ultrasonography, to post-treatment rehabilitation, symptom management and quality of life. Two new chapters on molecular prognostic and predictive markers, and sexuality and fertility issues in women with breast cancer, have been added. This is the 7th volume in the M.D. Anderson Cancer Care Series, featuring the best standard treatment protocols from the experts at M.D. Anderson Cancer Center.

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Breast Cancer (MD Anderson Cancer Care Series) Review

The second edition of Breast Cancer' MD Anderson Guide incorporated all important developments in breast cancer management: prevention, screening, and therapeutics were revised. It is a practical guide, with a direct language, showing how is the institutional routine at Nellie B. Connally Breast Center in MD Anderson. Perhaps the great message emerged from this book is the multidisciplinary approach to breast cancer care as the best practice today. Unfortunately this approach is not for all realities, and remains a great challenge for most centers in developing countries. But, at the end, it is a fast, complete, and practical review recommended for all breast specialists.

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Saturday, October 1, 2011

Clinical Emergency Medicine Casebook (Cambridge Medicine)

Clinical Emergency Medicine Casebook (Cambridge Medicine)

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Product Description

Emergency Medicine is not divided into specific areas of practice. Emergency room visitors come in all shapes and sizes, at any time of day or night, with a wide range of maladies. Emergency physicians need to become experts in diverse areas of medicine and to be able to make quick and informed decisions about patient care. A cornerstone of emergency medicine training is the constant drilling and re-drilling of simulated cases and clinical scenarios. This book offers a unique yet underutilized strategy for learning: a case-based approach from real patients and actual events. Each case provides the opportunity for learning essential clinical concepts. Focused exclusively on the needs of in-training emergency physicians and nurses, the book covers more than 100 common and unusual cases in emergency medicine. The procedures have been class-tested by the Stanford/Kaiser Emergency Medicine Residency Program.

Clinical Emergency Medicine Casebook (Cambridge Medicine) Review

Clinical Emergency Medicine Casebook lives up to its title as a clinically relevant reference. Categorized by major organ systems one gets the opportunity to review case presentations in a standardized format complete with copious illustrations. Be the super sleuth. Read the history, know the physical exam, have key evaluation parameters and take a stab at the diagnosis. Answers are thorough including key teaching points and references. Compare your work ups to those of the experts. Are you ordering too many or too few tests for a given complaint? Think about the last patient you saw with this presentation and see if you would have missed this diagnosis. Learn from the detailed and informative case reviews. It is a somewhat novel but very helpful approach to work towards the diagnosis, as we do everyday in real practice, rather than look up a condition and work backwards. With traditional methods of presentation we may be able to recite a litany of facts regarding any specific diagnosis but would we recognize it in the Emergency Department? Well written, thought provoking and educational. Well received by attendings and residents. Nice work Levis and Garmel!

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