The Organic Chemistry of Drug Design and Drug Action, Second Edition

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Product Description

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction.


* Presents an organic chemist's perspective of how drugs are designed and function
* Includes extensive references and illustrations, plus new problems and exercises to help students learn
* Written in a casual style that provides unmatched clarity and understanding
* Author has published 200+ articles, earned 21 patents, and invented a drug that is under consideration for commercialization

The Organic Chemistry of Drug Design and Drug Action, Second Edition Review

This is probably the best book of its kind in the vast and multidisciplinary field of drug design and action. Richard Silverman is an acclaimed chemistry professor at Northwestern University, and in this book he provides the most comprehensive and lucid exposition of the chemical basis of drug action that I have seen. No matter how complicated biological systems and their interactions are, at the basic level it's all chemistry, and mostly organic chemistry. Thus, understand the chemistry and you will go a long way in understanding drug action. An organic chemist will find this book extremely illuminating in a way that would not have been made clear through his traditional education.

The book opens with a short but clear discussion of drug discovery, combinatorial chemistry, patents and clinical trials. Then it leads the reader through a variety of enzyme catalyzed reactions, with examples of major drugs studded all the way. Silverman shows us how nature is the master organic chemist, employing the familiar reactions of chemistry in an unsurpassed manner. The chapter on enzyme inhibition is long and detailed and it's breathtaking. This is a key chapter because almost all major drugs act by inhibiting enzymes. The examples which Silverman chooses to illustrate are both important (including many bestselling anticancer, antiviral, and antibiotic drugs to name a few), as well as very interesting. The last parts of the book deal with DNA binding drugs and with pathways of drug metabolism and excretion. Along all the way, the emphasis is on the chemical reactions that drugs undergo, which are after all the key to understanding their properties. The lucidity of the book is such that a beginning graduate or advanced undergraduate well-versed with the basic principles of general and organic chemistry can easily understand all the contents.

I would say that this book is so interesting and illuminating that it's one of the very few academic books which you can enjoyably read cover to cover. In fact it even makes great bedside reading! Truly a must-have book for chemists and biologists of every kind interested in how drugs work.

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